Absorption of a drug by the cells requires that drug to be sufficiently non-polar to pass through the non-polar cell membrane.

Absorption of a drug by the cells requires that drug to be sufficiently non-polar to pass through the non-polar cell membrane. Therefore, the neutral molecules are absorbed more efficiently than the charged molecules by the cells of the human body.

Where will Ephedrine (Base, pKb = 4.4) be absorbed more effectively? (You can select one, two, or all) 

Hint: Determine the dominant (most abundant) form, base/conjugate acid at each region of the intestine to determine if the molecule is charged or not.  

a)Lower Stomach that has a pH = 2.0

b)Small Intestine that has a pH = 4.0

c)Large Intestine that has a pH = 6.0

d)None of the above

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