How does exercising the brain increase the chances of not building up plaque in communication pathways?
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I presume that the plaque being mentioned are the amyloid plaques characteristic of Alzheimer’s disease. Each time neural circuitry is used, molecular mediators of survival are released which strengthen that particular connection of circuitry. The more that pathway gets used, the more of these mediators are released, the more likely that circuit remains intact.

Conversely, even throughout adult life, circuits that are not used as much are not reinforced …

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