Persistent asthma: combination of inhaled corticosteroids and LABA (Long-Acting beta-Agonists)

Persistent asthma: combination of inhaled corticosteroids and LABA (Long-Acting beta-Agonists) in the prevention of exarcerbations: a systematic review? And then you can review randomized clinical trials that compare – e.g.: budesonide and formoterol with corticosteroids alone and/or with short acting beta agonists, in adults with persistent asthma. 1. Title 2. Your name, campus 3. Preceptor’s name, credentials, contact info 4. Month, year of submission 5. Background: study problem and /rationale/relevance of the project. No citations here! Objectives 6. Literature Review (what other people found out so far, are there recent or ongoing systematic reviews?) 7. Define the question: a clearly defined question will ensure that your research produces relevant results (you may use PICO to formulate an answerable question)*. 8. Study design: a systematic review 9. Research Methods a. Criteria for inclusion of studies in the review Types of Studies Study Types: Randomized controlled trials, prospective observational or retrospective studies, case control studies, etc. Depends on the research question ** Participant Types: you will review studies on certain type of patients (age, gender, ethnicity, degree of comorbidity, inpatient or outpatient etc). b. Definitions you will use in your research. c. Types of Intervention or the Phenomenon of Interest d. Types of Outcomes: what will be main, primary and secondary outcomes in the articles you will take into account in your review. You may rate the outcomes – e.g.: by the importance. You may measure outcomes. e. Search Strategy Databases,MESH terms, key words Language Timeframe f. Study selection (description of the procedure): EG: “To select the articles for the full-text review, we will start with screening the titles and abstracts and present screening process in the form of..” Usually we use PRISMA flow diagram to show how the articles will be selected. Similar screening tools can be used as well: PICOS worksheet and search strategy, PICOS flowchart*. g. Assessment of Methodological Quality Critical Appraisal You should tell us how will you assess the quality of articles. EG: For each research question, you may use appropriate CEBM appraisal worksheets. Other methods that can be used are: GRADE framework for the levels of quality of evidence: high, moderate, low, and very low (the quality of evidence is reflected as the extent to which one can be confident that an estimate of effect is correct and includes an explicit consideration of the following: risk of bias, inconsistency, indirectness, imprecision, and publication bias). For assessment of risk of bias and publication bias in articles, you may use Newcastle – Ottawa quality assessment scale. Note: in the final paper, we do not expect detailed report about the quality of each paper you reviewed. h. Data extraction, methods to synthesize and manage the data Usually data are presented in a form of a table that may include: information on the authors, country, study methodology, population, intervention, and relevant outcome measures. Please tell us what will your table contain. 10. Expected outcome (what you expect to achieve with your paper) 11. References and Appendices (if there are Appendices)

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