Tay- Sachs disease (TSD) is an inborn error of metabolism that results in death, often by the age of 2.

Tay-Sachs disease (TSD) is an inborn error of metabolism that results in death,

often by the age of 2. You are a genetic counselor interviewing a phenotypically

normal couple who tell you the male had a first f

emale cousin (on his father’s

side) who died from TSD and the female had a maternal uncle with TSD. There

are no other known cases in either of the families, and none of the matings have

been between related individuals. Assume that this trait is very rare

.

a) Draw the pedigree of the families of this couple, showing the related individuals

b) Calculate the probability that both the female and the male are carriers for TSD

a. Draw the pedigree of the families of this couple, showing the related individualsAnswer I1234 1234II Aa 5 66 aa Aa AA/Aa AA/Aa 7AA Aa Aa 123Figure: Pedigree showing inheritance of…

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