What are the known genetic and/or environmental factors that increase susceptibility?

Therapeutic Strategies for Non-malignant Leukocyte Disorders

Select one of the non-malignant leukocyte disorders from one of the two lists below.

Granulocyte & Monocyte Disorders

Chronic Granulomatous Disease

Chediak-Higashi Syndrome

Leukocyte Adhesion Deficiency

Hypereosinophilic Syndrome

Gaucher Disease

Lymphocyte Disorders

Infectious Mononucleosis

AIDS

X-linked SCID

ADA Deficiency

X-linked Agammaglobulinemia

Using information from your textbook, lecture, and additional online research, compose a brief report on your selected disease that answers the following questions. (Try to answer each question in no more than 5 sentences.)

1. What is the molecular defect that underlies this disease?
2. What is the frequency of its occurrence in the world?
3. Are there any particular susceptibility groups?
4. What are the known genetic and/or environmental factors that increase susceptibility?
5. What are the key clinical parameters used to diagnose this disease?
6. What are the greatest clinical consequences (patient symptoms) of this disease?
7. What is the general prognosis for patients with this disease?
8. What are the current treatment options for this disease?

• At the end of your report provide a provocative open-ended question to which your classmates can respond.
• Include a list of all references used to answer the questions, and be sure to indicate the source of your answers by using “in-text” citations